N-Cadherin Locks Left-Right Asymmetry

The group of Leonor Saúde publish in Developmental Cell: In chicken embryos, molecular asymmetries at Hensen’s node are created by leftward cell movements that occur transiently. We show that N-cadherin can prevent cells to continue indefinitely this movement, thus maintaining the already established asymmetries. We also show that when N-cadherin function is blocked the expression pattern of fgf8 and nodal in the node changes, leading to an altered asymmetry in the Lateral Plate Mesoderm. These findings indicate that asymmetric N-cadherin in the node locks the leftward cell movement and left-right asymmetry. See article here.