A clock in limb patterning

Caroline Sheeba, Raquel Andrade and Isabel Palmeirim have recently published a featured perspective article in the Journal of Molecular Biology. In this article they present an integrated temporal and spatial model for limb patterning, proposing that the limb Clock may allow temporal information to be decoded into positional information when the distance between opposing signaling gradients is no longer sufficient to provide distinct cell fate specification. The authors were also invited to prepare a figure for the cover of the Journal of Molecular Biology! See the JMB website.